One thing I'd really love fixed, from a console player's perspective at least, is the targeting.
There was a thread last year detailing some of the pain with it, but I'll reiterate it through a tale or two.
I was doing the quest to unlock Mirri. During this quest, I found my reticle not taking priority in which target was selected. So, for instance, my target reticle is pointed at the quest object. However, Mirri somehow opened her dialogue because she was between my camera and my reticle. Then in other situations, there's some distant grappling bow post that gets priority, even though I'm trying to activate something closer to me and my reticle.
Part of the issue here is Companion pathing, where they just keep getting in the way. The line between me and a lootable object should be sacrosanct. But the fundamental issue is really competing priorities in the looting system.
Then even looting and basic object interaction is problematic. I find I often jump, even though the loot/interact button prompt is available to me. It seems like prompts happen too soon. If a target is out of range, I shouldn't see a prompt until it's in range and interactable.
Also, when you enter a dungeon alone, there's nothing to indicate which version of the dungeon you're entering. It would be great if the dungeon name and version or something displayed on the screen for a few seconds upon entering. I know if you enter the dungeon through the door, IIRC (haven't done it for a while), it asks which version you want. But if you port in directly, there's nothing.