Oh, yes. Even more, they all are ancestors of my Skyrim character.
My character for main quest line, Redguard Hossul, was a friend with Freyrick Hust, who is now a husband to my another character, bosmer I created for Summerset quest line. As you can guess, Hossul and Freyrick broke up their relationship because Hossul thought Freyrick's wife was a bad choice for him. It is a very short version of what happened, at the moment I'm writing full story