Naga Chroma + Orb Weaver
Though, I've almost entirely ditched the Orb Weaver and primarily use my Black Widow X Chroma because I hate moving back-and-forth to type replies
My key layouts are identical on the KB and OW so I see no advantage to one over the other.
I could *NEVER* go back to the KB (or OW) for Skills after having purchased my first-gen Naga in 2012.
*EDIT*
On the OW my "Bar Swap" is right where my thumb rests (not the space button). On my KB I changed "Bar Swap" to ALT and have bound ALT to the #10 button on my Naga.
1 = 1
2 = 2
3 = 3
4 = 4
5 = 5
6 = R
7 = Weapon Sheath (RP!)
8 = Quick Slot
9 = Toggle Walk (RP!)
10 = ALT
11 = Mount
12 = Free Mouse
I also use Middle Mouse Click, Middle Mouse Wheel Left, Middle Mouse Wheel Right, etc. for things.
I've been using this layout since Beta. Never hit the wrong button.
The keyboard is basic movement and typing.