Maintenance for the week of March 24:
• PC/Mac: NA and EU megaservers for patch maintenance – March 24, 4:00AM EDT (8:00 UTC) - 10:00AM EDT (14:00 UTC)
• Xbox: NA and EU megaservers for patch maintenance – March 26, 6:00AM EDT (10:00 UTC) - 12:00PM EDT (16:00 UTC)
• Playstation®: NA and EU megaservers for patch maintenance – March 26, 6:00AM EDT (10:00 UTC) - 12:00PM EDT (16:00 UTC)
The enchantment itself does not cause Major Defile, but it has a 20% base chance to apply Diseased, a secondary effect of Disease Damage that deals direct damage and then applies a Major Defile.
Disease resistance from Glyphs or Racial Passives will make you immune to this secondary effect.
And poisons can be made to apply Minor Defile, but not Major.