This is primarily a PVP perspective, I'm not sure how significant this is in PVM.

Since U41 dropped, I've been having significant issues with targeting players in PVP. I always utilize tab target in PVP when fighting multiple people, but lately it feels like this adds no target priority whatsoever. I very frequently hit players that are not tab targeted and are not within my reticle when attempting to hit a person I have targeted, and often times will hit players that aren't even visible on screen in front of me (like firing an assassins' will at somebody who is standing behind me whilst aiming forwards at another player). Corpses and NPCS also seem to have some significant target priority over players, and will often be chosen as targets over players even when aiming directly at them. I have spoken to more than a dozen other PVP players regarding this, and the sentiment seems to be shared amongst all of them. Players utilizing both Gamepad and Mouse & Keyboard seem to be experiencing this. For me personally, this has drastically impacted how combat feels and has deteriorated the experience significantly.

Potion Usage appears to have been directly changed as well. It genuinely seems that potions are attached to the global cooldown in some way now. There will be times where I press the keybind for my potion multiple times while in a fast paced encounter, and I'm never able to get it to actually fire despite hearing the audio queue. While there have been some minor issues with potions firing for a while now, this patch has undeniably introduced some new level of obstruction to their use. I often need to cease all functions other than basic movement in order to actually get my potions to fire.

Would love to hear from anybody that may be experiencing the same thing or something similar.