As an alchemist my potion select is very limited thank to the negative effects of some reagent, I come up with an alternative solution to replace the negative effects of these reagents, so that why we can create more diverse of potions.
1.Ravage magicka = preserve magicka (cost reduction )
2. Ravage stamina = preserve stamina
3. Lower armor = restore armor
4. Reduce speed = strength (light & heavy attack do extra damage )
5. Ravage health = preserve health ( damage taken reduction )
6. Stun = courage ( immune to fear)
7. Lower spell power = soulless ( drain emenies magicka )
8. Lower spell resistance = explosion ( aoe damage )
9. Lower spell critical = toxic ( dot damage )
10. Lower weapon power = exhaustion ( drain emenies stamina )
11. Lower weapon critical = damage shield