I've encountered this bug numerous times so far. What happens is you go into combat, initiate, and then... None of your buttons work. You see the clicks on the buttons themselves on the ability like it's being pressed, but it doesn't work. Reloading the UI tends to fix it, but it's not something you can do in combat without dying. Especially if you initiate and are squishy, as absolutely no abilities work. You can possibly block, but you can't even melee attack anything. Please fix Zenimax, you are our only hope.