There are several sets that reduce opponent spell damage such as Alessia's Bulwark which reduces spell damage by 300. How much spell damage do bosses and mobs typically have? Is 300 a significant reduction in their damage output?
Overall, you can get significant damage reduction around 15-30% with the right setup, but as with anything in the game, there are diminishing returns if you build too much for damage reduction.
And obviously, the damage you take depends on your resistances and which dungeon mode you're in.
This one wants to know what happens when you combine an Infused Weakening enchant with Heartland Conqueror, Torug's Pact and enchant-boosting visions in Endless Archive. I mean, at some point marauders must surely start giving you health, when they hit you .