There are 3 options from what I've seen and experienced this patch.
1. Use a resistance set i.e. pariaha/ Master armour/ Orgnum Scale with a sustain/ damage set.
2. Invest in health recovery with sets that boost it i.e. Troll king or maj Vitality such as Scourage harvester.
For me I personally, I don't like either of the above options so I go with the 3rd.
3. Run at least 4/5 well-fit and avoid damage with Roll dodges and LoS. Active defence is much better than banking on passive defense.
Its a lot different now with builds to find tankiness /damage and sustain this patch compared to before.