It will still suffer from the same issues that it always has: you'll either have to split your investments into crit/penetration/CP, or neglect one of your damage pools.
Easier to use one resource for damage, the other for buffs. Pelinals, shackle, innate are a good place to start.
Edit: its even more doable now. When Vet ranks were a thing, I soloed Spindleclutch at VR1 on a Hybrid DW Nightblade. I thought it was a delve lol. We have been through so many battles together and he never let me down when it got tough.