It did for me (on a Mac though, and track pad so it was double press). I swapped block and jump, so spacebar now blocks and RMB jumps. Took me about 2 runs to get used to it, but it works for me.
It happens to me quite often. I play on PC but I use a controller. At first I thought I was running out of stamina but I watched closely and it wasn't a stamina issue.
I've had this issue here and there, no idea why it happens. Could be lag but idk. Its also really hard to document because obviously I can't prove I was still holding up block. I do notice it in conjunction with certain skills being fired on me like meteor especially. But not always.