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"If you want others to be happy, practice compassion. If you want to be happy, practice compassion." -- the 14th Dalai Lama Wisdom is doing Now that which benefits you later.
Yeah so let's say my Critical Rush says 2000 Damage and my Crit Damage multiplier is 1.5x.
When I cast it on an enemy, it'll do (2000 * 1.5) = 3000 Damage, not including damage mitigation from CP/Armor/Spell Resistance.
But when you do cast it on someone who has a damage shield, it'll just hit for stated tooltip damage, unless I'm wrong of course and there's some other factors.