Low Health
When at low health, the screen gains a red tint. At very low health, sounds also become muffled as the red tint takes up the entire screen space.
When playing as a vampire, it's possible to not have passive health regen, so staying at low health persists.
For some reason these health based visual and audio ques remain even while in a game of TOT. It's distracting and messes with the experience of playing a round of cards. Yes, this issue is easy to not cause, but game states following players into a match of TOT also just spells out larger trouble since it could possibly open up the door to abusing this mechanic some how for an advantage. I have no idea how, it just seems like such states should follow players into unrelated game modes.
Talking to NPCs
I accepted a TOT match while taling to a Guild Trader NPC. The game was unplayable. Again, I don't know why accepting a match TOT can't disengage a player from whatever game state they are in when entering the match.