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I think it only lowers damage from disease based skills...which aren't many.
It lowers all disease damage, by ~6% on top of your physical resist. Enchants are the one most people care about. And it makes you immune to to the diseased status effect, you don't get hit by the small amount of damage from the proc nor do you get major defile put on you.
Edited by Lightspeedflashb14_ESO on April 23, 2018 3:57AM
You'll still be defiled by a Lethal Arrow or Incap for example. But a disease weapon enchantment, even with charged trait wont proc defile on you
This is correct, that's how it is, but the damage from the enchant is only mitigation. So still take damage. But It will also stop the the defile from the disease damage abilities like say killers blade. It has a ten percent chance of procing defile. But a skill that specific applied defile, no. Cheers.