Lightspeedflashb14_ESO wrote: »Yes. I have done it a lot. Just /reloadui after.
Addons only affect the ui, and the only way to load a nw addon is by relogging or /reloadui. Since reloadui reloads all addons you're essentially never loading an addon mid playthrough. It's basically restarting the game as far as adons are concerned. That said, if for some reason you wanted t and made a way to do so, you most likely could load an addon mid playthrough with no problems.