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[vMA endboss] will a imunity to knockback and disabling potion help?
Yes but it's still in your best interest to either block or dodge them. IIRC the skull is Oblivion damage which is unreduceable and the meteors up top pack a real punch.
Same thing with the Ash Titan, I swear that flame circle is designed to one-shot you if you don't get out of the way (even with an immunity potion active).
You should never be getting hit by the boss's skull. You should also never be getting hit by the red circles up top. It's a learn2play issue. You need more practice.