Saw my fps go from 70 to 15 in Alik'r on the quest with the farmhands and the rain maker, where you have the vial and you go find which oasis is corrupted. Every time I would enter the water of the different oasis' to check, I would see huge lag/frame rate drops, only time I've ever seen this outside of Cyrodil.
Also, the lizard for the quest where the lizard sniffs out the traitor is busted, the lizard literally just beelines for a place with no one there and nothing there, and then disappears. Makes the quest unfinishable.