Yes, the books are part of the lore, as far as I can tell, since they are official releases. However, keep in mind that the lore of TES is not always 100% accurate to the truth, and indeed many of the authors are biased or possibly mistaken.



So for the Agents and Reagents, most of the alchemy stuff looks pretty normal, though I didnt double check every reagent's properties.

The enchanting stuff is different. Some of the items listed have been used as Alchemy reagents in the other games, like Frost salts, ectoplasm, most flesh, and glow dust. Others haven't been used at all, like the gem chalcedony, vampire teeth, and snake parts. A few appear as trophies in ESO, like the netch membranes.



As for Kyne's Challenge, I second the request for you to elaborate. Theres a lot,of text to skim and I'm not seeing any problems jump out at me. Its basically a tour of the different regions and their major monster types. From my brief overview, the monsters are present in the listed zones, though also found in other zones as well. The daedra are mostly present in those zones, those I think a few were sprinkled in where the story required them.

So overall, yes they are lore-friendly, though perhaps not 100% acurate, rather like much of the in-game lorebooks.

As I said, most of the enchanting stuff is present in some way in the series, if not always in the way described in the book.


Not Used At All (as far as I can tell, please correct if I missed them somewhere)
Chalcedony
Porphyry
Lazurite
Jasper
Animal skins (crafting mats)
Slag, embers, and Ash (possibly the Heartstones from Dragonborn DLC)
Blue Ice
Giant's thumb and teeth
Gilint Splinter
Skybolt
Vampire Fangs (just dust)
Cold Blood
Small Heart
Snake Parts


Trophies in ESO
Netch Membranes
Carapace
Daedra Husk
Dwarven Cogs and Gear
Insect parts
Lizard Parts
Skull&bones
Shock ball (crackling lodestone)
Guts (fishing bait)


Alchemy Reagents in other TES Games
Animal claws
Carapace (Mudcrab Chitin)
Dwarven Oil
Frost Salts
White Ice (described as Ice Wealth Teeth)
Glow Dust
Ectoplasm
Giant's Toe
Taproot
Creep Cluster
Briarheart
Bonemeal
Blood Salts
Vampire Dust
Mort Flesh
Void Salts
Fire Salts
Daedra Hearts