2E 521 — Emeric is born. Emeric, the future King of Wayrest and leader of the Daggerfall Covenant, is born to Pierric of Cumberland.

2E 541 — The Reachmen invade High Rock. Durcorach the Black Drake, Emperor of the Empire of Cyrodiil and progenitor of the Longhouse Emperors, invades the land of the Bretons, but is defeated by the kingdoms of High Rock and slain by Emeric. The kings of Daggerfall, Camlorn, Shornhelm, Evermore, and Wayrest sign the first Daggerfall Covenant after the victory.

2E 546 — Jorunn is born. Jorunn, the future High King of Skyrim and leader of the Ebonheart Pact, is born to Queen Mabjaarn Flame-Hair of Windhelm.

2E 555 — Ayrenn is born. Ayrenn, the future Queen of Alinor and leader of the Aldmeri Dominion, is born on the 5th of Second Seed to King Hidellith and Kinlady Tuinden of Summerset Isle.

2E 560 — The Knahaten Flu spreads across Tamriel. A strain of the Knahaten Flu hits the southern provinces of Tamriel causing many deaths. The Argonians were strangely immune to the flu which has led some to believe that they were responsible for it in some way. The flu continued until around 2E 603.

2E 563 — The Voyage of the Crimson Ship occurs. A vessel filled with Kothringi tribesmen fleeing from the Knahaten Flu leaves Black Marsh on 9 First Seed. After spending over a year being turned away from port after port, it sets sail to the west and is never seen again.

2E 563 — Emeric is crowned King of Wayrest.

2E 567 — The Greater Daggerfall Covenant is formed. Following the events of Ranser's War, the provinces of High Rock and Hammerfell sign the Second Daggerfall Covenant with the Orcs of Orsinium.

2E 572 — The Akaviri invaders of Morrowind are defeated. The Akaviri invaders are killed when the land mysteriously becomes flooded. Despite the extensive flooding, almost no Dunmer people are injured or killed. Legend has it that the god Vivec taught the Dunmeri to breathe water and flooded the island.

Another version of the event states Ada'Soom Dir-Kamal landed in northeast Skyrim with an Akaviri army and proceeded to capture Windhelm. En route to Riften, Dir-Kamal learned it was protected by forces under Jorunn the Skald-King and Wulfharth the Ash-King, and bypassed that city in favor of attacking Mournhold. Dir-Kamal was then trapped between Jorunn's forces and a Dunmer army led by Almalexia; with the timely aid of a phalanx of Argonian troops, they drove the Akaviri invaders into the sea to drown.

2E 572 — Jorunn the Skald-King is crowned High King of Skyrim. Having defeated the Akaviri invaders, Jorunn returns to Windhelm and is crowned High King of Skyrim in the throne room of the Palace of the Kings.

2E 572 — The Ebonheart Pact is formed. Following the Second Akaviri Invasion, the provinces of Morrowind, Skyrim and Black Marsh sign a mutual defensive pact in the city of Ebonheart.

2E 573 — Emperor Leovic of Cyrodiil is overthrown by Varen Aquilarios. Leovic, the last of a dynasty of Reachmen known as the Longhouse Emperors, legalizes Daedra worship, immediately sparking a rebellion. Varen Aquilarios, the Duke of Chorrol, marshals the armies of the Colovian Estates against Leovic. After a long and bitter war, Varen kills Leovic in the Imperial Throne Room and proclaims himself emperor.

2E 577 — Emperor Varen Aquilarios leads the Five Companions on a quest to retrieve the Amulet of Kings. Seeking to legitimize his rule, Varen and his allies Lyris Titanborn, Sai Sahan, Abnur Tharn, and Mannimarco embark on a quest for the lost Amulet of Kings, which Mannimarco asserts can be used in a ritual to persuade Akatosh to make Varen a Dragonborn. After two years of searching, the Five Companions finally recover the Amulet from Sancre Tor.

2E 578 — The Soulburst occurs;

Mannimarco betrays Varen Aquilarios during his attempt to use the Amulet of Kings to become Dragonborn, corrupting the ritual and breaking the ancient covenant with Akatosh that sealed Nirn from Oblivion. An explosion of arcane energy, the Soulburst, causes Varen to vanish, and its mystical aftershocks sweep across Nirn, causing mages to die or go mad, Daedra to appear in greater numbers, and the constellation of the Serpent to dominate the night sky. In the ensuing chaos, the Daedric Prince Molag Bal deploys Dark Anchors to begin pulling Nirn into his realm of Coldharbour to merge the two together, a process known as the Planemeld.

2E 579 — Clivia Tharn becomes Empress Regent following the disappearance of Varen Aquilarios. In her husband's absence, Clivia Tharn assumes regency over the Imperial Throne. Clivia's reign reportedly ushers in a time of "madness, murder, and decay".

2E 580 — Ayrenn is crowned Queen of Alinor. After disappearing in 2E 563, Ayrenn was assumed lost and her eldest brother Prince Naemon was named the next heir to the throne. When King Hidellith died and Naemon prepared to assume the throne, Ayrenn returned to Summerset Isle, asserted her prior claim, and was crowned.

2E 580 — The First Aldmeri Dominion is formed. In need of allies following their own internal troubles, the provinces of Elsweyr and Valenwood petition Summerset for aid, and the nations join together to become the Aldmeri Dominion.

2E 582 — The Three Banners War begins. The Aldmeri Dominion, Ebonheart Pact and Daggerfall Covenant clash to wrest control of the Ruby Throne from the Empire of Cyrodiil and defend themselves against the Imperials under Molag Bal's influence. The Dominion seeks to reestablish Elven dominance over Tamriel to protect it from the carelessness of the younger races. The Covenant intends to restore the Second Empire and return peace and stability to Tamriel. The Pact desires to defeat the Imperials in order to preserve the independence of their homelands.