I find recently that the camera sensitivity on gamepad for turning is rather low even on the highest level. Also the responsiveness for certain skills; for example especially channeled skills like arcanist or templar beam after you get interrupted or repeat them, same as elemental drain; you kinda have to light attack in between otherwise the game doesnt seem to recognise that you want to beam again...
But i dont know if this is an issue due to my gamepad or a general issue (Using Razer Wolverine 3 with a 2.4ghz dongle)