I don't know if this is better off in the bug report forum, but I don't see any ToT bugs mentioned in there.
If I try to click on a patron (to purchase their boon) right before the announced effect of a card I just plays pops up, I am unable to finish clicking on the patron after I have obtained the card, knocked out the other player's agent, cleared cards from the tavern etc. The patron I tried to click on gets a blue ring around it, and I am unable to click on it or any other patron. I can still purchase cards and end the turn. I can interact normally with the patrons the following turn. I am assuming this is a bug and not an intentional punishment for clicking on a patron before the game is finished announcing the effects of the cards you just played.