Everyone says you should keep your deck small so you can keep playing your good cards more frequently and get more combinations, so I assume you're also advised to focus on the cards of a single patron.
But I seem to be doing okay by having a larger deck with cards of multiple patrons. I can get combinations fairly regularly, sometimes even for two different patrons at once, especially if I'm able to look ahead and pick two or more cards to discard from the top of my draw pile.
Is that just because I've only played against NPCs so far? Is it just dumb luck coupled with weak AI?
I've fought mudcrabs more fearsome than me!