I'm working on my third playthrough of a character and have noticed a particular problem with each class of character I have played. I have noticed that the Harvester Daedra, the snake like female daedra with many arms, have a damage ramp up that can potentially one shot your character no matter what. I usually successfully managed to overcome them while questing, but there is a particular quest where I notice that they have always been an real pain, during the Halls of Torment main quest. In the second chamber where you fight the elite Harvestor, she smashes my characters faces in no matter how well I avoid or stop her attacks. I'll be fighting when suddenly my character, who was at full health, suddenly drops dead in an instant. It seems that they have a critical damage attack that is way off the charts.
Even the random ones I encounter while questing do this as well, but there are normally other players around so it isn't so noticable. These particular NPCs are the absolute worst to encounter in the game for that particular reason. I understand their attacks and abilities, but they often have so much going on it leaves little room for error. They are spamming AOE attacks if you get close to them and if you try to go ranged, they hit you like a truck consistently with a ranged spell. They need to be toned down a lot. These are literally the only NPCs in the game I have had any problems with, because as I said, it isn't because I am making mistakes as, I learned how to fight the different mobs in the game through trial and error, but these particular ones seem to one shot me quite often, enough to raise an alarm. Even with a health food buff for HP and points in HP, they still manage to one shot me at full health, that simply should not happen.
What made me realize that there was a problem, was that these one shot kills always seem to happen shortly after they used one of their charged attacks that I successfully avoided, meaning, that it's just one of their random spammy attacks that are killing me in one hit, not a power attack. Even still I manage to survive the occasional AOE attack from them without taking much damage, it's just as I said, one of their random attacks suddenly kills me out of the blue. It always shocks me every time, because I will be closely monitoring my health and suddenly, ZAP, I'm dead. It's seems like they have crit/damage that is scaled way above my character's levels.
I've noticed a lot of bugs while playing the game, but this is really the only one that has bothered me enough to mention it.