So this game kinda has an input/delay problem. Take for instance, the Siren fight in Morrowind. Her high damage ability pops up, spam the synergy key, nothing happens, take a ton of damage.
How about no more of those. Also maybe removing the existing ones until synergies actually work reliably.
"Never go in, miss. Never say a prayer at its door. If you are angry, do not seek revenge by the Laughing Maiden Stone, or at the threshold of the Tombs. There be those who listen for oaths and vows...What may be said in innocence and ire becomes flesh and blood in such places."
-Old Marsh